Other terms
Graefe Disease,Disease, Graefe,Mitochondrial Ocular Myopathy,Mitochondrial Ocular Myopathies,Myopathies, Mitochondrial Ocular,Myopathy, Mitochondrial Ocular,Ocular Myopathies, Mitochondrial,Ocular Myopathy, Mitochondrial,Progressive External Ophthalmoplegia,Graefe's Disease,Graefes Disease,Ocular Myopathy of Von Graefe-Fuchs,Ocular Myopathy of Von Graefe Fuchs,Ophthalmoplegia, Progressive External,External Ophthalmoplegia, Progressive,External Ophthalmoplegias, Progressive,Ophthalmoplegias, Progressive External,Progressive External Ophthalmoplegias,CPEO,Ocular Muscular Dystrophy,Dystrophies, Ocular Muscular,Dystrophy, Ocular Muscular,Muscular Dystrophies, Ocular,Muscular Dystrophy, Ocular,Ocular Muscular Dystrophies
Description
Ophthalmoplegia, Chronic Progressive External: A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
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