Other terms
Autoimmune Neuritis, Experimental,EAN (Experimental Allergic Neuritis),Neuritis, Experimental Autoimmune,Experimental Allergic Neuritis,Experimental Autoimmune Neuritis,Experimental Autoimmune Neuropathy,Autoimmune Neuropathies, Experimental,Autoimmune Neuropathy, Experimental,Experimental Autoimmune Neuropathies,Neuropathies, Experimental Autoimmune,Neuropathy, Experimental Autoimmune,Neuritis, Experimental Allergic,Allergic Neuritis, Experimental,EAN (Experimental Autoimmune Neuritis)
Description
Neuritis, Autoimmune, Experimental: An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
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