Other terms
Cytochrome P 450 Enzyme System,Cytochrome P-450,Cytochrome P 450,Cytochrome P450,Cytochrome P-450 Monooxygenase,Cytochrome P 450 Monooxygenase,Monooxygenase, Cytochrome P-450,Cytochrome P-450-Dependent Monooxygenase,Cytochrome P 450 Dependent Monooxygenase,Monooxygenase, Cytochrome P-450-Dependent,Cytochrome P-450 Oxygenase,Cytochrome P 450 Oxygenase
Description
Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
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