Other terms
Fusion Proteins, bcr abl,bcr-abl Fusion Proteins,bcr abl Fusion Proteins,Oncogene Protein p190(bcr-abl),p190(bcr-abl) Fusion Proteins,Oncogene Protein p210(bcr-abl),p210(bcr-abl) Fusion Proteins
Description
Fusion Proteins, bcr-abl: Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. The p210(bcr-abl) fusion protein is found in patients with LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE. The p190(bcr-abl) fusion protein is found in patients with PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in ABELSON MURINE LEUKEMIA VIRUS.
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