Other terms
Pregnancy Associated Plasma Protein A,IGFBP-4 Protease,IGFBP 4 Protease,Protease, IGFBP-4,IGFBP-4-Specific Proteinase,Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease,Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease,PAPP-A,PAPP-alpha,PAPP alpha,Pregnancy Associated alpha Plasma Protein,Pregnancy-Associated alpha-Plasma Protein,IGFBP-4 Metalloproteinase,IGFBP 4 Metalloproteinase,Metalloproteinase, IGFBP-4,Insulin-Like-Growth Factor Binding Protein-4 Protease,Insulin Like Growth Factor Binding Protein 4 Protease
Description
Pregnancy-Associated Plasma Protein-A: A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.
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