Other terms
Amyloid beta Protein Precursor,beta-Protein Precursor, Amyloid,beta-Amyloid Protein Precursor,beta Amyloid Protein Precursor,Amyloid Protein Precursor,Amyloid A4 Protein Precursor,Amyloid beta Precursor Protein
Description
Amyloid beta-Protein Precursor: A precursor to the AMYLOID BETA-PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.
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