Other terms
Kininogen, High Molecular Weight,High Molecular Weight Kininogens,Kininogens, High Molecular Weight,HMWK,High-Molecular-Weight Kininogens,Kininogens, High-Molecular-Weight,High-Molecular-Weight Kininogen,Fitzgerald Factor,High Molecular Weight Kininogen
Description
Kininogen, High-Molecular-Weight: A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
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