Other terms
Insertional Mutagenesis,Sequence Insertion,Insertion, Sequence,Insertions, Sequence,Sequence Insertions,Viral Insertional Mutagenesis,Insertional Mutagenesis, Viral,Mutagenesis, Viral Insertional,Linker-Insertion Mutagenesis,Linker Insertion Mutagenesis,Mutagenesis, Linker-Insertion,Gene Insertion,Gene Insertions,Insertion, Gene,Insertions, Gene,Insertion Mutation,Insertion Mutations,Mutation, Insertion,Mutations, Insertion,Insertional Activation,Activation, Insertional,Activations, Insertional,Insertional Activations,Mutagenesis, Cassette,Cassette Mutagenesis
Description
Mutagenesis, Insertional: Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
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