Other terms
Cell Leukodystrophies, Globoid,Cell Leukodystrophy, Globoid,Globoid Cell Leukodystrophies,Leukodystrophies, Globoid Cell,Galactosylceramidase Deficiency Disease,Deficiency Disease, Galactosylceramidase,Deficiency Diseases, Galactosylceramidase,Disease, Galactosylceramidase Deficiency,Diseases, Galactosylceramidase Deficiency,Galactosylceramidase Deficiency Diseases,Galactosylceramide-beta-Galactosidase Deficiency Disease,Deficiency Disease, Galactosylceramide-beta-Galactosidase,Deficiency Diseases, Galactosylceramide-beta-Galactosidase,Disease, Galactosylceramide-beta-Galactosidase Deficiency,Diseases, Galactosylceramide-beta-Galactosidase Deficiency,Galactosylceramide beta Galactosidase Deficiency Disease,Galactosylceramide-beta-Galactosidase Deficiency Diseases,Globoid Body Sclerosis, Diffuse,Krabbe's Leukodystrophy,Krabbes Leukodystrophy,Leukodystrophy, Krabbe's,Globoid Cell Leukoencephalopathy,Cell Leukoencephalopathies, Globoid,Cell Leukoencephalopathy, Globoid,Globoid Cell Leukoencephalopathies,Leukoencephalopathies, Globoid Cell,Leukoencephalopathy, Globoid Cell,Globoid Leukodystrophy,Globoid Leukodystrophies,Leukodystrophies, Globoid,Leukodystrophy, Globoid,Krabbe Disease,Krabbe Leukodystrophy,Leukodystrophy, Krabbe,Krabbe's Disease,Krabbes Disease,Diffuse Globoid Body Sclerosis,Globoid Cell Leukodystrophy,Late-Onset Globoid Cell Leukodystrophy,Late Onset Globoid Cell Leukodystrophy,Leukodystrophy, Globoid Cell, Late-Onset,Early-Onset Globoid Cell Leukodystrophy,Early Onset Globoid Cell Leukodystrophy,Leukodystrophy, Globoid Cell, Infantile,Leukodystrophy, Globoid Cell, Classic,Leukodystrophy, Globoid Cell, Early-Onset,Classic Globoid Cell Leukodystrophy,Infantile Globoid Cell Leukodystrophy
Description
Leukodystrophy, Globoid Cell: An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.
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