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Charcot-Marie-Tooth DiseaseLegal notice  


Other terms
Charcot Marie Tooth Disease,Charcot-Marie Disease,Charcot Marie Disease,Peroneal Muscular Atrophy,Atrophy, Muscular, Peroneal,Muscular Atrophy, Peroneal,Atrophies, Peroneal Muscular,Atrophy, Peroneal Muscular,Muscular Atrophies, Peroneal,Peroneal Muscular Atrophies,Roussy-Levy Syndrome,Roussy Levy Syndrome,Syndrome, Roussy-Levy,Hereditary Areflexic Dystasia,Areflexic Dystasia, Hereditary,Areflexic Dystasias, Hereditary,Dystasia, Hereditary Areflexic,Dystasias, Hereditary Areflexic,Hereditary Areflexic Dystasias,Roussy Levy Hereditary Areflexic Dystasia,Roussy-Levy Disease,Roussy Levy Disease,Hereditary Type I Motor and Sensory Neuropathy,Hereditary Motor, and Sensory Neuropathy Type I,Neuropathy, Type I Hereditary Motor and Sensory,HMSN I,HMSN Is,Is, HMSN,HMSN Type I,HMSN Type Is,Charcot-Marie-Tooth Disease, Type I,Charcot Marie Tooth Disease, Type I,HMN Distal Type I,HMSN Type II,HMSN Type IIs,Type IIs, HMSN,Neuropathy, Type II Hereditary Motor and Sensory,HMSN II,HMSN IIs,Charcot-Marie-Tooth Disease, Type II,Charcot Marie Tooth Disease, Type II,Hereditary Motor and Sensory-Neuropathy Type II,Hereditary Motor and Sensory Neuropathy Type II,Charcot-Marie-Tooth Disease, Type Ia,Charcot Marie Tooth Disease, Type Ia,Charcot-Marie-Tooth Disease, Type Ib,Charcot Marie Tooth Disease, Type Ib

Description
Charcot-Marie-Tooth Disease: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)



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