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Spastic Paraplegia, HereditaryLegal notice  


Other terms
Hereditary Spastic Paraplegias,Paraplegia, Hereditary Spastic,Paraplegias, Hereditary Spastic,Spastic Paraplegias, Hereditary,Hereditary Spastic Paraplegia,Paraplegia, Spastic, Hereditary,Type V Hereditary Motor and Sensory Neuropathy,Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia,Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia,HMSN V (Hereditary Motor and Sensory Neuropathy Type V),Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy,Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy,HMSN Type V,Type V, HMSN,Hereditary Motor-Sensory Neuropathy with Pyramidal Signs,Hereditary Motor Sensory Neuropathy with Pyramidal Signs,Hereditary X-Linked Recessive Spastic Paraplegia,Hereditary X Linked Recessive Spastic Paraplegia,X-linked Recessive Hereditary Spastic Paraplegia,X linked Recessive Hereditary Spastic Paraplegia,Spastic Paraplegia, X-Linked Recessive, Hereditary,Hereditary, Spastic Paraplegia, X-Linked Recessive,Spastic Paraplegia, Hereditary, X-Linked Recessive,Hereditary Autosomal Dominant Spastic Paraplegia,Hereditary, Spastic Paraplegia, Autosomal Dominant,Spastic Paraplegia, Autosomal Dominant, Hereditary,Spastic Paraplegia, Hereditary, Autosomal Dominant,Autosomal Dominant Spastic Paraplegia Hereditary,Autosomal Dominant Hereditary Spastic Paraplegia,X-Linked, Spastic Paraplegia, Hereditary,Autosomal Recessive Hereditary Spastic Paraplegia,Autosomal Recessive Spastic Paraplegia, Hereditary,Spastic Paraplegia, Hereditary, Autosomal Recessive,Hereditary Spastic Paraplegia, Autosomal Recessive,Hereditary Autosomal Recessive Spastic Paraplegia,Spastic Paraplegia, Autosomal Recessive, Hereditary

Description
Spastic Paraplegia, Hereditary: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)



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