Other terms
Cholesterol Side Chain Cleavage Enzyme,20,22-Desmolase,20,22 Desmolase,Cholesterol Desmolase,Cytochrome P450 11A1,CYP 11A1,CYP11A1,Cytochrome P-450 CYP11A1,Cytochrome P 450 CYP11A1,Cytochrome P-450(scc),Cytochrome P450scc,Cholesterol Monooxygenase (Side-Chain-Cleaving)
Description
Cholesterol Side-Chain Cleavage Enzyme: A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
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