Other terms
IRS Signaling Adaptor Proteins,Insulin Receptor Substrate-2 Protein,Insulin Receptor Substrate 2 Protein,Insulin Receptor Substrate-2,Insulin Receptor Substrate 2,Insulin Receptor Substrate-4 Protein,Insulin Receptor Substrate 4 Protein,Insulin Receptor Substrate-4,Insulin Receptor Substrate 4,Insulin Receptor Substrate-1 Protein,Insulin Receptor Substrate 1 Protein,Insulin Receptor Substrate-1,Insulin Receptor Substrate 1,Insulin Receptor Substrate-3 Protein,Insulin Receptor Substrate 3 Protein,Insulin Receptor Substrate-3,Insulin Receptor Substrate 3
Description
Insulin Receptor Substrate Proteins: A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share in common an N-terminal PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation insulin receptor substrate proteins interact with specific SH2 DOMAIN-containing proteins that are involved in insulin receptor signaling.
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