Other terms
25 Hydroxyvitamin D3 1 alpha Hydroxylase,25-Hydroxyvitamin D2 1-hydroxylase,1-hydroxylase, 25-Hydroxyvitamin D2,25 Hydroxyvitamin D2 1 hydroxylase,CYP27B1,Cytochrome P-450 CYP27B1,Cytochrome P 450 CYP27B1,Calcidiol 1-Monooxygenase,Calcidiol 1 Monooxygenase,25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase,25-Hydroxyvitamin D 1-alpha-Hydroxylase,1-alpha-Hydroxylase, 25-Hydroxyvitamin D,25 Hydroxyvitamin D 1 alpha Hydroxylase,25-Hydroxycholecalciferol-1-Hydroxylase,25-Hydroxycholecalciferol 1-Hydroxylase,25 Hydroxycholecalciferol 1 Hydroxylase,25-Hydroxyergocalciferol 1-alpha-Hydroxylase,1-alpha-Hydroxylase, 25-Hydroxyergocalciferol,25 Hydroxyergocalciferol 1 alpha Hydroxylase
Description
25-Hydroxyvitamin D3 1-alpha-Hydroxylase: A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
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