Other terms
Metabolic Detoxication, Oxidative,Detoxication, Oxidative Metabolic,Detoxications, Oxidative Metabolic,Metabolic Detoxications, Oxidative,Oxidative Metabolic Detoxication,Oxidative Metabolic Detoxications,Phase I Detoxification,Detoxification, Phase I,Detoxifications, Phase I,Metabolic Detoxification, Phase I
Description
Metabolic Detoxication, Phase I: Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
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